Research Articles
54.
Analysis of Antiangiogenic Potential and Cell Death Mechanism of a Kinetically Inert Platinum Antitumor Agent.
Manikandan M, Sushanta Chhatar, Saurabh Dey, Tushar Ranjan Panda, Sourav Chakraborty, Pritha Ray, Chinmoy Patra*, Malay Patra*
ACS Med. Chem. Lett. 2024, https://doi.org/10.1021/acsmedchemlett.4c00207
53.
Autophagy-mediated ID1 turnover dictates chemo-resistant fate in ovarian cancer stem cells.
Pratham Phadte, Aniketh Bishnu, Pranay Dey, Manikandan M, Megha Mehrotra, Prerna Singh, Shritama Chakrabarty, Rounak Majumdar, Bharat Rekhi, Malay Patra, Abhijit De & Pritha Ray*.
J. Exp. Clin. Cancer Res., 2024, 43, 222. https://doi.org/10.1186/s13046-024-03147-z
52.
Synthesis and Characterization of organoselenium based BODIPY and its application in living cells.
D. S. Shelar, G. S. Malankar, S. S. Salunkhe, M. Manikandan, A. D. Chavan, R. V. Pinjari, M. Patra*, R. J. Butcher, S. T. Manjare*
Bioorganic Chemistry , 2024, 150, 107568
51.
Necrosis Inducing High Valent Oxo-Rhenium(V) Complexes with Potent Antitumor Activity: Synthesis, Aquation Chemistry, Platinum Cross-Resistance Profile and Mechanism of Action.
S. Das, P. Joshi, M. Patra* Inorg. Chem., 2023, 62, 19720-19733.
50.
Improving In Vivo Tumor Accumulation and Efficacy of Platinum Antitumor Agents by Electronic Tuning of the Kinetic Lability.
Manikandan M, S. Chhatar, S. Gadre, S. Paul, S. P. Vaidya, S. Khatri, P. Duari, J. Kode, A. Ingle, U. K.-Seetharam, M. Patra*
Chem. Eur. J., 2023, e202302720.
49.
A Hydrolytically Stable Oxo-Rhenium(V) Antitumor Agent for Synergistic Combination Therapy with Cisplatin: From Synthesis and Mechanistic Studies to Toxicity Assessment in Zebrafish.
S. P. Vaidya, M. Manikandan, S. Chhatar, S. Dey, M. Patra* Inorg. Chem. Front. 2023, 10, 6711-6727
48.
Development of A Highly In Vivo Efficacious Dual Antitumor and Antiangiogenic Organoiridium Complex as Potential Anti-Lung Cancer Agent.
S. Gadre, Manikandan, M, G. Chakraborty, A. Rayrikar, S. Paul, C. Patra, M. Patra* J. Med. Chem., 2023, 66, 13481-13500.
47.
The Power of Kinetic Inertness in Improving Platinum Anticancer Therapy by Circumventing Resistance and Ameliorating Nephrotoxicity.
Tushar Ranjan Panda, Manikandan M, Shreyas P. Vaidya, Sushanta Chhatar, Suman Sinha, Megha Mehrotra, Sourav Chakraborty, Shubhankar Gadre, Prakash Duari, Pritha Ray,* and Malay Patra* Angew. Chem. Int. Ed. 2023, 62, e202303958
Selected as Frontispiece for the issue.
46.
TCA cycle tailoring facilitates optimal growth of proton-pumping NADH dehydrogenase-dependent Escherichia coli.
N. Goel, S. Srivastav, A. Patel, A. Shirsath, T. R. Panda, M. Patra, A. M. Feist, A. Anand*, Microbiology Spectrum, 2023, DOI: https://doi.org/10.1128/spectrum.02225-23.
45.
Synthesis of selenium-based BOPHY sensor for imaging of Cu (II) in living HeLa cells.
G. S. Malankar, D. S. Shelar, M. Manikandan, M. Patra*, S. T. Manjare*, J. Mol. Struc., 2023, 1281, 135118.
44.
A Potent Ruthenium-Ferrocene Bimetallic Antiproliferative Antiangiogenic Agent that Circumvents Platinum Resistance in Ovarian Cancer Cells: From Synthesis and In-depth Mechanistic Studies to in vivo Evaluation in Zebrafish.
Manikandan M., S. Gadre, S. Chhatar, G. Chakraborty, N. Ahmed, C. Patra,* Malay Patra,* J. Med. Chem. 2022, 65, 24, 16353–16371
43.
A Rationally Designed Bimetallic Platinum (II)-Ferrocene Antitumor Agent Induces Non-Apoptotic Cell Death and Exerts in Vivo Efficacy.
S. Gadre, M. Manikandan, P. Duari, S. Chhatar, A. Sharma, S. Khatri, J. Kode, M. Barkume, N. K. Kasinathan, M. Nagare, M. Patkar, A. Ingle, M. Kumar, U. K.-Seetharam, M. Patra*, Chem. Eur. J., 2022, 28, e202201259.
42.
Selective Detection of Hypochlorous Acid in Living Cervical Cancer Cells with Organoselenium Based BOPPY Probe.
D. S. Shelar, G. S. Malankar, M. Manikandan, M. Patra*, R. J. Butcher, S. T. Manjare*, New. J. Chem., 2022, DOI:https://doi.org/10.1039/D2NJ02956A
41.
A BOPHY based fluorescent probe for Hg2+ via NTe2 chelation.
G. S. Malankar, D. S. Shelar, M. Manikandan, M. Patra*, R. J. Butcher, S. T. Manjare*, Dalton Trans., 2022, 51, 10069-10076.
40.
Synthesis and Biological Evaluation of Metallocene-Tethered Peptidyl Inhibitors of CDC25.
S. Roy, L. Rangasamy, A. Nouar, C. Koenig, V. Pierroz, S. Kaeppeli, S. Ferrari, M. Patra*, and G. Gasser*, Organometallics, 2021, 40, 2716-2723.
39.
Increased Lipophilicity of Halogenated Ruthenium (II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro When Used as Photosensitizers for Photodynamic Therapy.
S. Roy, E. Colombo, R. Vinck, C. Mari, R. Rubbiani, M. Patra* and G. Gasser*, ChemBioChem, 2020, 21, 2966-2973.
38.
Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 23 89Zr-radiolabeled monoclonal antibodies.
A. Guillou, D. F. Earley, M. Patra, J. P. Holland*, Nature Protocol, 2020, 15, 3579-3595.
37.
A Ru(II) polypyridyl complex bearing aldehyde functions as a versatilesynthetic precursor for long-wavelength absorbing photodynamic therapyphotosensitizers.
J. Karges, F. Heinemann, F. Maschietto, M. Patra, O. Blacque, I. Ciofini, B. Spingler, G. Gasser*, Bioorg. Med. Chem., 2019, 27, 2666-2675.
36.
Simultaneous PhotoradiochemicalLabeling of Antibodiesfor Immuno-Positron Emission Tomography.
M. Patra, S. Klingler, L. S. Eichenberger, J. P. Holland, iScience, 2019, 13, 416-431. Open access.
35.
Photochemical Conjugation and One-Pot Radiolabeling of Antibodies for Immuno-PET.
M. Patra, L. Eichenberger, G. Fisher, J. Holland*, Angew. Chem. Int. Ed., 2019, 58, 1928-1933.
34.
Photoactive chelates for radiolabelling proteins.
L. S. Eichenberger, M. Patra, J. P. Holland, Chem. Commun., 2019, 55, 2257-2260.
33.
Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles.
S. H. Yu, M. Patra, S. Ferrari, P. R. Garcia, N. A. Veldhuis, L. M. Kaminskas, B. Graham, J. F. Quinn, M. R. Whittaker,* Gilles Gasser* and Thomas P. Davis*, J. Mat. Chem. B., 2018, 6, 7805-7810.
32.
Mesoporous silica nanoparticles functionalised with a photoactive ruthenium(II) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser.
Y. Ellahioui, M. Patra, C. Mari, R. Kaabi, G. Gasser* and S, Gómez-Ruiz,* Dalton Trans., 2019, 48, 5940-5951
31.
ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links.
K. Mutreja, J. Krietsch, J. Hess, S. Ursich, M. Berti, F. Roessler, R. Zellweger, M. Patra, G. Gasser, M. Lopes*, Cell Reports, 2018, 24, 2629-2642.
Before Joining TIFR
30.
Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium.
J. Hess, G. Panic, M. Patra, L. Mastrobuoni, S. Roy, J. Keiser*, G. Gasser* ACS Infect. Dis., 2017, 3, 645-652.
29.
Influence of the Dissolution Solvent on the Cytotoxicity of Octahedral Cationic Ir(III) Hydride Complexes.
H. Huang, N. Humbert, V. Bizet, M. Patra, H. Chao, Clément Mazet, and Gilles Gasser, J. Organomet. Chem., 2017, 839, 15-18.
28.
Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo
M. Patra, S. G. Awuah and S. J. Lippard*, J. Am. Chem. Soc., 2016, 138, 12541-12551. Highlighted in ACS Chem. Biol.
27.
A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells.
M. Patra, T. C. Johnstone, K. Suntharalingam, S. J. Lippard*, Angew. Chem. Int. Ed., 2016, 55, 2550-2554.
26.
Synthesis, Characterization and Biological Activity of Ferrocenyl Derivatives of the Anthelmintic Drug Monepantel.
J. Hess, M. Patra, V. Pierroz, B. Spingler, A. Jabbar, S. Ferrari, R. B. Gasser,* and G. Gasser,* Organometallics, 2016, 35, 3369-3377.
25.
Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Anti-parasitic Drug Candidates.
J. Hess, M. Patra, L. Rangasamy, S. Konatschnig, O. Blacque, A. Jabbar, P. Mac, E. M. Jorgensen, R. B. Gasser,* G. Gasser,* Chem. Eur. J., 2016, 22, 16602-16612.
24.
Assessment of the Nematocidal Activity of Metallocenyl Analogues of Monepantel.
J. Hess, M. Patra, A. Jabbar, V. Pierroz, S. Konatschnig, B. Spingler, S. Ferrari, R. B. Gasser,* and G. Gasser,* Dalton Trans. 2016, 45, 17662-17671.
23.
Dual mode of cell death induced by photo-activation of a DNA intercalating RuII polypyridyl complex.
V. Pierroz, R. Rubbiani, C. Gentili, M. Patra, C. Mari, G. Gasser and S. Ferrari,* Chem. Sci., 2016, 7, 6115-6124.
22.
Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma Mansoni.
S. Clède, N. Cowan, F. Lambert, H. C. Bertrand, R. Rubbiani, M. Patra, J. Hess, C. Sandt, N. Trcera, G. Gasser,* J. Keiser* and C. Policar,* ChemBioChem, 2016, 17, 1004-1007.
21
An Organometallic Structure-Activity Relationship Study Reveals the Essential Role of a Re(CO)3 Moiety in the Activity Against Gram-Positive Pathogens Including MRSA.
M. Patra, M. Wenzel, P. Prochnow, V. Pierroz, G. Gasser, J. E. Bandow* and N. Metzler-Nolte*, Chem. Sci., 2015, 6, 214-224.
20
An Octadentate Bifunctional Chelating Agent for the Development of Stable Zirconium-89 Based Molecular Imaging Probes.
M. Patra, A. Bauman, C. Mari, C. A. Fischer, O. Blacque, D. Haussinger, G. Gasser,* T. L. Mindt,* Chem. Commun., 2014, 50, 11523-11525.
19
DNA Intercalating Ru(II) Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy.
C. Mari, V. Pierroz, R. Rubbiani, M. Patra, J. Hess, B. Spingler, L. Oehninger, J. Schur, I. Ott, L. Salassa, S. Ferrari and G. Gasser,* Chem. Eur. J., 2014, 20, 14421-14436.
18
Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni.
I. Meister, K. Ingram-Sieber, N. Cowan, M. Todd, M. N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser,* Antimicrob. Agents Chemother., 2014, 58, 5466-5472.
17.
Synthesis of Ferrocenyl and Ruthenocenyl Thioamide Derivatives Using a Single-Step Three-Component Reaction.
M. Patra,* J. Hess, S. Konatschnig, B. Spingler, G. Gasser,* Organometallics, 2013, 32, 6095-6105.
16.
DMSO-mediated Ligand Dissociation: Renaissance for Biological Activity of N-heterocyclic-[Ru(η6-arene)(Cl2)] Drug Candidates.
M. Patra,* T. Joshi, V. Pierroz, K. Ingram, M. Kaiser, S. Ferrari, B. Spingler, J. Keiser and G. Gasser*, Chem. Eur. J., 2013, 19, 14768-14772.
15.
Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics.
M. Patra §, M. Wenzel §, C. H. R. Senges, J. J. Stepanek, A. Pinto, P. Prochnow, I. Ott, N. Metzler-Nolte*, J. E. Bandow*, ACS Chem. Biol. 2013, 8, 1442-1450 (§ = co-first authors).
14.
Di-Heterometalation of Thiol-Functionalized Peptide Nucleic Acids.
T. Joshi, M. Patra, L. Spiccia and G. Gasser*, Artificial DNA: PNA & XNA, 2013, 4, 11-18.
13.
An Environmentally-Benign and Cost-Effective Synthesis of Aminoferrocene and Aminoruthenocene.
A. Leonidova, T. Joshi, D. Nipkow, A. Frei, J. Penner, S. Konatschnig, M. Patra and G. Gasser*, Organometallics, 2013, 32, 2037-2040.
12.
In Vitro Metabolic Profile and In Vivo Antischistosomal Activity Studies of (η6-Praziquantel)Cr(CO)3 Derivatives.
M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M. N. Robertson, M. H. Todd, J. Keiser,* G. Gasser,* J. Med. Chem., 2013, 56, 9191-9198.
11.
Cr(CO)3-Praziquantel Derivatives with Remarkable In Vitro Antischistosomal Activity.
M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, J. Keiser,* and G. Gasser,* Chem. Eur. J., 2012, 19, 2232-2235.
10.
Ferrocenyl Derivatives of the Anthelmintic Praziquantel: Design, Synthesis and Biological Evaluation.
M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, J. Keiser and G. Gasser,* J. Med. Chem., 2012, 55, 8790-8798.
9.
Sandwich and Half-sandwich Derivatives of Platensimycin: Synthesis and Biological Evaluation.
M. Patra, G. Gasser, M. Wenzel, K. Merz, J. E. Bandow and N. Metzler-Nolte,* Organometallics, 2012, 31, 5760-5771.
8.
Planar Chiral (η6-arene)Cr(CO)3 Containing Carboxylic Acid Derivatives: Synthesis and Use in the Preparation of Organometallic Analogue of the Antibiotic Platensimycin Lead Structure.
M. Patra, K. Merz and N. Metzler-Nolte,* Dalton Trans., 2012, 41, 112-117.
7.
Azidomethyl-ruthenocene: Facile Synthesis of a Useful Metallocene Derivative and its Application in the ‘Click’ Labeling of Biomolecules.
M. Patra and N. Metzler-Nolte,* Chem. Commun., 2011, 47, 11444-11446.
6.
Synthesis of Optically Active Ferrocene-containing Platensimycin Derivatives with a C6-C7 Substitution Pattern.
M. Patra, G. Gasser, M. Wenzel, K. Merz, J. E. Bandow and N. Metzler-Nolte,* Eur. J. Inorg. Chem., 2011, 3295-3303
5.
Proteomic Signature of Fatty Acid Biosynthesis Inhibition Available for In Vivo Mechanism-of-Action Studies.
M. Wenzel, M. Patra, D. Albrecht, D. Y.-K. Chen, K. C. Nicolaou, N. Metzler-Nolte, J. E. Bandow,* Antimicrob. Agents Chemother., 2011, 55, 2590-2596.
4.
Synthesis and Biological Evaluation of Ferrocene-containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure.
M. Patra, G. Gasser, M. Wenzel, K. Merz, J. E. Bandow and N. Metzler-Nolte,* Organometallics, 2010, 29, 4312-4319.
3.
Sequential Insertion of Three Different Organometallics into a Versatile Building Block Containing a PNA Backbone.
M. Patra, G. Gasser,* D. Bobukhov, K. Merz, A. V. Shtemenko and N. Metzler-Nolte,* Dalton Trans., 2010, 39, 5617-5619.
2.
Synthesis and Biological Evaluation of Chromium Bioorganometallics Based on the Antibiotic Platensimycin Lead Structure.
M. Patra, G. Gasser, K. Merz, I. Ott, J. E. B. and N. Metzler-Nolte,* ChemMedChem, 2009, 4, 1930-1938.
1.
Formation, Reactivity, and Photo-release of Metal Bound Nitrosyl in [Ru(trpy)(L)(NO)]n+ (trpy = 2,2':6',2''-terpyridine, L = 2-phenylimidazo-[4,5-f]- 1,10-phenanthroline).
S. Maji, B. Sarkar, M. Patra, A. K. Das, S. M. Mobin and G. K. Lahiri,* Inorg. Chem., 2008, 47, 3218-3227.